Highly Sensitive Electrochemical Detection of Pomalidomide Using a Novel NiCuSe<sub>2</sub>/MnCoFe LTH Nanocomposite Sensor: Application to Real Sample Analysis
ACS OMEGA, vol.10, no.25, pp.26605-26617, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 10 Issue: 25
- Publication Date: 2025
- Doi Number: 10.1021/acsomega.5c00694
- Journal Name: ACS OMEGA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Directory of Open Access Journals
- Page Numbers: pp.26605-26617
- Kocaeli University Affiliated: No
Abstract
A novel electrochemical sensor for the quantification of Pomalidomide (POMA) is introduced in the present work, based on a glassy carbon electrode (GCE) modified with a unique NiCuSe2/MnCoFe layered triple hydroxide (LTH) composite. In this regard, the novel NiCuSe2/MnCoFe LTH composite was synthesized and characterized using various structural and morphological techniques, confirming its successful formation. The electrochemical properties of the composite were evaluated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), providing its high conductivity, superior electrocatalytic activity, and rapid electron transfer capabilities. The NiCuSe2/MnCoFe LTH-modified GCE was utilized for the detection and quantification of POMA using differential pulse voltammetry (DPV). The developed sensor exhibited an impressive linear detection range of 0.02-10.3 mu M and an ultralow detection limit of 4.7 nM. Furthermore, it demonstrated exceptional selectivity, reproducibility, and repeatability. Finally, the sensor was applied to analyze POMA in some real samples: pharmaceutical capsules, human urine, and human blood serum.