MLL-AF4 gene rearrangement in a child with Epstein-Baff virus-related posttransplant B-cell lymphoma


Corapcioglu F., Olgun N., Sarialioglu F., Uysal K., Oren H., Sercan O.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.25, no.9, pp.740-742, 2003 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 9
  • Publication Date: 2003
  • Title of Journal : JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Page Numbers: pp.740-742

Abstract

Recipients of solid organ allografts are known to be at increased risk of developing Epstein-Barr virus-related posttransplant lymphoproliferative diseases. A 28-month-old boy who had received a heterotopic liver transplant presented with lymphadenopathy in the abdomen, multiple nodules in the liver, and bilateral renal infiltration 19 months after transplantation. He was diagnosed with a Burkitt-like lymphoma based on bone marrow examination and the finding that the blastic cells in bone marrow were EBER-1 positive. Cytogenetic analysis of the bone marrow cells showed an MLL-AF4 rearrangement. He was treated with a combined chemotherapy regimen. He has been in continuous complete remission for 15 months now.