Turkiye Klinikleri J Med Res, cilt.18, ss.114-120, 2000 (Diğer Kurumların Hakemli Dergileri)
In this study, adrenal glands of female mice which were
administered a combined oral contraceptive (COC) including
ethinyl estradiol+ethynadiol diacetate for one year were examined
light microscopically. Total dimensions and thickness of cortex and its zones and thickness of medulla in adrenal glands were evaluated according to morphometric data with micrometric ocular in the treatment and the control groups. Nodular construction in zona reticularis (21.3%), excessive lipid vacuolization (12.3%) and leucocytic infiltration (0.62%) in cortex and slight changes in dimensions of the adrenal glands were observed in COC administered mice. It was concluded that, low doses of COC cause no significant morphometric changes, but it provokes some histopathologic changes in the adrenal glands.
Key Words: Ethinyl estradiol, Ethynadiol diacetate, Adrenal glands
T Klin J Med Res 2000, 18:114-120