Does removal of CU-IUD in patients with biofilm forming candida really maintain regression of clinical symptoms?


Cakiroglu Y., Caliskan S., Doger E., Ozcan S., Caliskan E.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.35, no.6, pp.600-603, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3109/01443615.2014.986442
  • Title of Journal : JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Page Numbers: pp.600-603

Abstract

Objective: To evaluate whether symptoms and recurrence would differ with and without Cu-IUD removal in patients with concomitant biofilm forming Candida spp. Methods : The data of 270 consecutive patients wearing TCu380A Cu-IUD were evaluated. Among these patients, 100/270 were found to have Candida spp. isolated from the tail of Cu-IUD or vaginal samples. These patients were investigated in four groups: Group 1 (n = 24; Biofi lm (+), Cu-IUD removed), Group 2 (n = 14; Biofi lm (+), Cu-IUD not removed), Group 3 (n = 29; Biofi lm (-), Cu-IUD removed), Group 4 (n = 33; Biofi lm (-), Cu-IUD not removed). Patients in each group were followed for clinical signs and symptoms for 8-16 months and compared to each other. Results : Symptoms, physical findings and candida positivity have decreased statistically significantly in Group 1 one year after removal of Cu-IUD (95.8% vs. 4.2%, p < 0.01; 95.8% vs. 4.2%, p < 0.01; 100% vs. 8.3%, p < 0.01 respectively). In Group 2, symptoms, physical findings and candida positivity have decreased after follow-up, but without a statistical significance. In Group 3, all the parameters have decreased, but only decrease in candida positivity has reached statistical significance (100% vs. 48.3%, p < 0.01). In Group 4-as in Group 1-symptoms, physical findings and candida positivity have decreased statistically significantly (48.5% vs. 18.2%, p = 0.01; 72.7% vs. 48.5%, p = 0.05; 100% vs. 51.5%, p < 0.01 respectively). Conclusion : Biofi lm forming microorganisms should be considered in the management of vaginal infections or symptoms for safer use of intrauterine devices.