In WLAN networks, channel assignment is highly critical due to adjacent and co-channel interference problems. Considering the lack of channel numbers for 2.4 GHz Wi-Fi bands, adjacent interference, and co-channel interference are mostly unavoidable. Channel assignment can be challenging when some access points are too many, or access point locations are not fixed. In this work, we present a comparison two different channel assignment algorithms, Minimum-Spanning Tree-Inspired (MISTI) and Signal to Interference Ratio (SIR) based, and conclude the simulated experimental results regarding interference power and SIR performances. Furthermore, we have planned to select which channel assignment model has better results under several different scenarios prepared for the comparison. Moreover, MISTI and SIR based algorithm results are mostly close to each other except the latter has some fluctuations in terms of related metrics. Hence, this study has prepared to make a valid comparison between two proposed algorithms by simulating experimental results.