The role of cystatin-C and fetuin-A in the determination of early atherosclerotic risk in psoriasis patients


Demirbas A. , Kurtipek G. S. , Tuncez A., Akyurek F., Demirbas G. U.

DERMATOLOGIC THERAPY, vol.33, no.6, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.1111/dth.13898
  • Title of Journal : DERMATOLOGIC THERAPY
  • Keywords: atherosclerosis, carotid intima-media thickness, cystatin-C, fetuin-A, psoriasis, INTIMA-MEDIA THICKNESS, CORONARY-HEART-DISEASE, CARDIOVASCULAR RISK, SUBCLINICAL ATHEROSCLEROSIS, CAROTID ATHEROSCLEROSIS, REACTIVE PROTEIN, SERUM, ARTERY, MARKER, PREVALENCE

Abstract

Psoriasis is associated with an increased risk of atherosclerosis. The objective of this study is evaluate the relationship between carotid intima-media thickness (CIMT) serum and cystatin-C, fetuin-A levels in determining the increased risk of subclinical atherosclerosis in psoriasis patients. In this study, age and gender compatible 80 psoriasis patients and 78 healthy individuals were included. For both groups, serum cystatin-C, fetuin-A, high-sensitivity C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, total cholesterol, and creatinine levels were recorded and carotid intima-media thickness (CIMT) was measured via B-mode ultrasonography by cardiology department. In binary comparisons between patient and control groups, cystatin-C, fetuin-A, hs-CRP, and CIMT values were higher in psoriasis patients and there was a statistically significant difference (P < .05). In control group, serum HDL-C level was statistically significant higher (P < .05). There was no statistically significant difference in hs-CRP, ox-LDL, LDL-C, triglyceride, total cholesterol, and creatinine levels between the groups (P > .05). Our study supported that psoriasis is a risk factor for development of atherosclerosis and we think that cystatin-C can be used as an important marker in determining subclinical atherosclerosis in patients with psoriasis.