Akademik Veri Yönetim Sistemi
The 2rd European Congress on Dermato-Oncology (Dermato-Oncology 2025), Paris, Fransa, 17 - 18 Kasım 2025, sa.31, ss.44, (Özet Bildiri)
Radiotherapy and Cutaneous Mastocytosis: A Rare Association? Semanur Çakir Serinbaş1 , Rebiay Kiran1 , Dilek Bayramgürler1 , Büşra Özbek2 1Department of Dermatology, Kocaeli University Faculty of Medicine, Turkey 2Department of Pathology, Kocaeli University Faculty of Medicine, Turkey
This case report describes two patients: a 52-year-old woman who received 50 Gy of radiotherapy to the right breast 16 years ago and has presented with skin lesions for the past 6 years, and another 55-year-old woman who underwent radioactive iodine treatment for papillary thyroid cancer 10 years ago and has been followed for cutaneous mastocytosis for 6 years. In the first case, a biopsy revealed mast cells and eosinophils in the papillary dermis with a lymphohistiocytic infiltrate, which was positive for tryptase and CD117, with elevated serum tryptase levels. Bone marrow analysis was not performed, and a provisional diagnosis of “cutaneous mastocytosis” (CM) was made, with close follow-up due to the potential of systemic mastocytosis (SM). In the second case, bone marrow biopsy did not meet the criteria for systemic mastocytosis, but the patient showed clinical improvement with treatment that included omalizumab and PUVA therapy. These two cases represent the first reported instances of radiotherapy-induced mastocytosis in Turkey, and they are among the rare examples found in the literature. To date, only 13 cases of radiotherapy-induced cutaneous and systemic mastocytosis have been reported, and the pathogenesis remains unclear. It is hypothesized that clonal mast cell proliferation is triggered in the irradiated area in association with the Koebner phenomenon. This case emphasizes the need for further investigation into the effects of radiotherapy on mast cells, the relationship between mast cells and malignancies, and the rare complications of radiotherapy