Anaphylactic reaction after fluorescein sodium administration during intracranial surgery

Dilek O., Ihsan A., Tulay H.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.18, no.3, pp.430-431, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jocn.2010.06.012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.430-431
  • Keywords: Anaphylactic reaction, Fluorescein sodium, Glioma surgery, TECHNICAL NOTE, GLIOBLASTOMA-MULTIFORME
  • Kocaeli University Affiliated: Yes


We present a male patient who underwent a fluorescein sodium-guided brain tumor excision and experienced an anaphylactic reaction with severe hypotension and bradycardia. A 54-year-old, 70 kg man of American Society of Anesthesiologists status II was seen with a history of glioma. In the 80th minute of the operation, 20 mg/kg intravenous (i.v.) fluorescein sodium was injected after dural opening. A few minutes later, the anaphylactic reaction was diagnosed. Surgery was ended and the patient was delivered to the intensive care unit with intubation. Laboratory values were: immunoglobulin E, 332 U (upper limit 100 U); and elevated tryptase, 3.12 mg/dL. In view of the expanding use of fluorescein sodium in clinical procedures, physicians should be alerted to this rare but life-threatening adverse event. (C) 2010 Elsevier Ltd. All rights reserved.