The aim of this study is to design of a small size implantable antenna involving Industrial, Scientific and Medical (ISM) (2.4 GHz-2.48 GHz) band. The goal of designing antenna is to obtain physiological information pertaining to person. Simulation measurements of antenna were obtained in body ambient by making the design of antenna with CST Studio Suite programme. Then, in vitro measurements were performed on antenna by making an artificial material, which shows electrical features of human skin tissue, to verify measurement results. Obtained measurement results and simulative results are in accordance. © 2011 IEEE.