Low serum insulin-like growth factor-1 in patients with erectile dysfunction

Otunctemur A., Ozbek E., Sahin S., Ozcan L., Dursun M., Polat E. C., ...More

BASIC AND CLINICAL ANDROLOGY, vol.26, 2016 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2016
  • Doi Number: 10.1186/s12610-015-0028-x
  • Journal Name: BASIC AND CLINICAL ANDROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: Endothelial dysfunction, Erectile dysfunction, Insulin-like growth factor-1, International Index of Erectile Function Score-5
  • Kocaeli University Affiliated: Yes

Abstract

Objective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED.