Effects of chronic ethanol treatment on glial fibrillary acidic protein expression in adult rat optic nerve: an immunocytochemical study

Gonca S., Filiz S., Dalçık C., Yardimoglu M., Dalçık H., Yazır Y., ...Daha Fazla

CELL BIOLOGY INTERNATIONAL, cilt.29, sa.2, ss.169-172, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.cellbi.2004.11.020
  • Dergi Adı: CELL BIOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.169-172
  • Anahtar Kelimeler: glial fibrillary acidic protein, astrocyte, chronic ethanol treatment, optic nerve, immunocytochemistry, rat, WITHDRAWAL SYNDROME, EXPOSURE, CONSUMPTION, ASTROCYTES, BRAIN, HEAD
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Glial fibrillary acidic protein (GFAP) is used as a marker of astrocyte response to various central nervous system injuries. In the present study, the effects of chronic ethanol administration on GFAP immunoreactivity were evaluated in astrocytes of the adult optic nerve head. The results demonstrated that ethanol exposure significantly and dramatically increases GFAP immunoreactivity and the number of immunoreactive astrocytes (p<0.001). In addition, GFAP immunoreactive cells in the optic nerve showed extensive hypertrophy (p<0.001). (C) 2004 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.