Selective nuclear factor kappa-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin

Tugcu V., Ozbek E., Tasci A. I. , Kemahli E., Somay A., Bas M., ...More

BJU INTERNATIONAL, vol.98, no.3, pp.680-686, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1464-410x.2006.06321.x
  • Journal Name: BJU INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.680-686
  • Kocaeli University Affiliated: No

Abstract

OBJECTIVE To investigate the effect of selective nuclear factor kappa-B (NF kappa-B) inhibitors, pyrolidium dithiocarbamate (PD) and sulfasalazine (SZ) on renal tubular necrosis and inducible nitric oxide synthase (iNOS) and NF kappa-B expression induced by gentamicin in rats.