Controlled lithium discontinuation in bipolar patients with good response to long-term lithium prophylaxis

Yazici O., Kora K., Polat A. Ö., Saylan M.

JOURNAL OF AFFECTIVE DISORDERS, vol.80, pp.269-271, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80
  • Publication Date: 2004
  • Doi Number: 10.1016/s0165-0327(03)00133-2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.269-271
  • Kocaeli University Affiliated: Yes


Background: This study aims to investigate whether the risk of recurrence following lithium discontinuation is less than reported in discontinuation of a successful, long-term prophylaxis in bipolar patients. Methods: A total of 32 bipolar patients discontinued lithium according to the controlled lithium discontinuation (CLD) protocol following a definite good response to lithium maintenance of at least 5 years. Subjects were followed for up to 9 years. Results: The total rate of recurrence was 7% in the first week, 32% in the first month, 62% in the first year, and 81% at the end of the 9th year following discontinuation. Only six of the 32 patients (19%) did not have a recurrence during the follow-up period. Conclusions: Discontinuation of lithium seems to be followed by a high rate of recurrence in bipolar patients even after good response to a long-duration illness-free period. A controlled discontinuation protocol can reduce the risks of morbidity. (C) 2003 Elsevier B.V. All rights reserved.