An experimental study evaluating the effect of mitomycin C on the prevention of postoperative intraabdominal adhesions


Cubukcu A., Alponat A., Gonullu N., Ozkan S., Ercin C.

JOURNAL OF SURGICAL RESEARCH, cilt.96, ss.163-166, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 96 Konu: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1006/jsre.2000.6059
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayısı: ss.163-166

Özet

Background. Fibroblast proliferation is one of the well-known mechanisms for postoperative intraabdominal adhesion formation. Inhibition of fibroblast proliferation is an attractive field of investigation in the prevention of adhesions. Mitomycin C (MMC) is a cytotoxic agent that alkylates and crosslinks DNA and also inhibits fibroblast proliferation up to a few weeks. We aimed to determine the effect of MMC on the prevention of adhesions.