An experimental study evaluating the effect of mitomycin C on the prevention of postoperative intraabdominal adhesions

Cubukcu A., Alponat A., Gonullu N., Ozkan S., Ercin C.

JOURNAL OF SURGICAL RESEARCH, vol.96, no.2, pp.163-166, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 2
  • Publication Date: 2001
  • Doi Number: 10.1006/jsre.2000.6059
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.163-166
  • Kocaeli University Affiliated: No

Abstract

Background. Fibroblast proliferation is one of the well-known mechanisms for postoperative intraabdominal adhesion formation. Inhibition of fibroblast proliferation is an attractive field of investigation in the prevention of adhesions. Mitomycin C (MMC) is a cytotoxic agent that alkylates and crosslinks DNA and also inhibits fibroblast proliferation up to a few weeks. We aimed to determine the effect of MMC on the prevention of adhesions.