Aerogel-Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease-Targeting Applications

Karamikamkar S., Yalcintas E. P., Haghniaz R., De Barros N. R., Mecwan M., Nasiri R., ...Daha Fazla

ADVANCED SCIENCE, cilt.10, sa.23, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 10 Sayı: 23
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/advs.202204681
  • Dergi Adı: ADVANCED SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Applied Science & Technology Source, Compendex, EMBASE, INSPEC, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: additive manufacturing, aerogel, diagnosis, drug delivery, microfluidics, tissue engineering, wound healing, SUPERCRITICAL-FLUID TECHNOLOGY, BACTERIAL CELLULOSE AEROGELS, CONTROLLED DRUG-DELIVERY, SOL-GEL SYNTHESIS, SILICA AEROGEL, GRAPHENE AEROGEL, HYBRID AEROGELS, CARBON NANOTUBE, COMPOSITE AEROGELS, AMBIENT-PRESSURE
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Aerogel-based biomaterials are increasingly being considered for biomedical applications due to their unique properties such as high porosity, hierarchical porous network, and large specific pore surface area. Depending on the pore size of the aerogel, biological effects such as cell adhesion, fluid absorption, oxygen permeability, and metabolite exchange can be altered. Based on the diverse potential of aerogels in biomedical applications, this paper provides a comprehensive review of fabrication processes including sol-gel, aging, drying, and self-assembly along with the materials that can be used to form aerogels. In addition to the technology utilizing aerogel itself, it also provides insight into the applicability of aerogel based on additive manufacturing technology. To this end, how microfluidic-based technologies and 3D printing can be combined with aerogel-based materials for biomedical applications is discussed. Furthermore, previously reported examples of aerogels for regenerative medicine and biomedical applications are thoroughly reviewed. A wide range of applications with aerogels including wound healing, drug delivery, tissue engineering, and diagnostics are demonstrated. Finally, the prospects for aerogel-based biomedical applications are presented. The understanding of the fabrication, modification, and applicability of aerogels through this study is expected to shed light on the biomedical utilization of aerogels.