Akademik Veri Yönetim Sistemi
Current Concepts and Innovative Research in Health Sciences, Prof. Dr. Fatih HATİPOĞLU, Editör, All Sciences Academy, Konya, ss.57-75, 2025
Migraine is increasingly understood not only as a pain disorder but as a brain condition related to impaired physiological homeostasis and insufficient clearance of inflammatory and metabolic byproducts. Recent insights emphasize that the brain possesses a unique fluid transport system that becomes highly active during deep sleep, allowing the removal of potentially harmful substances that accumulate during wakefulness. In individuals with migraine, this natural clearance mechanism appears to become progressively overloaded or dysregulated, especially as attacks become more frequent or sleep quality deteriorates. In the early stages of migraine, the brain is often still able to compensate by enhancing its internal cleansing mechanisms. However, when this compensatory capacity begins to fail, migraine no longer remains a purely episodic phenomenon. Instead, the brain remains in a persistent hypersensitive state, even between attacks, which may contribute to cognitive fog, sensory overload, or constant head pressure. This shift marks the transition toward a chronic phase, during which responsiveness to conventional pain-suppressing treatments frequently declines. For this reason, contemporary therapeutic perspectives emphasize that effective migraine management should aim not only to suppress pain but also to support the brain’s intrinsic ability to recover. Protecting deep sleep quality, regulating autonomic balance, and enhancing fluid drainage within the brain are increasingly considered essential strategies to prevent disease progression and maintain long-term neurological resilience.