Infliximab prevents dysfunction of the vas deferens by suppressing inflammation and oxidative stress in rats with chronic stress

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Demirtaş Şahin T., Gocmez S. S., Duruksu G., Yazir Y., Utkan T.

LIFE SCIENCES, cilt.250, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 250
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.lfs.2020.117545
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Unpredictable chronic mild stress, Vas deferens, Inflammation, Oxidative stress, Infliximab, CHRONIC MILD STRESS, COGNITIVE IMPAIRMENT, ANIMAL-MODEL, DEPRESSION, INHIBITION, BEHAVIOR, STIMULATION, ANXIETY, BRAIN
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Aims: Chronic stress leads to the development of male sexual problems such as ejaculatory dysfunctions. The rhythmic contractions of vas deferens (VD) play an important role on the ejaculatory process. In the current study, we investigated whether infliximab (IFX) treatment has any beneficial effects on possible alterations in contractility of VD obtained from rats exposed to unpredictable chronic mild stress (UCMS).