Protective effects of apocynin on damaged testes of rats exposed to methotrexate.

Kavram Sarıhan K., Yardimoğlu Y., Eraldemir F. C., Yazir Y., Acar E.

Turkish journal of medical sciences, vol.50, pp.1409-1420, 2020 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-1909-52
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1409-1420
  • Keywords: Testis, methotrexate, apocynin, apoptosis, INDUCED TESTICULAR TOXICITY, INDUCED OXIDATIVE STRESS, MALE-FERTILITY, GERM-CELLS, VITAMIN-E, APOPTOSIS, MELATONIN, INJURY, CHEMOTHERAPY, THERAPY
  • Kocaeli University Affiliated: Yes

Abstract

Background/aim: Methotrexate (MTX), widely used as a drug in cancer, has many adverse effects on tissues. Apocynin (APO) is a NADPH oxidase inhibitor and is known with many antioxidant properties. In this study, we aimed to evaluate the adverse effects of MTX on testicular tissue and the protective effects of APO at two different doses (20 mg/kg and 50 mg/kg) on MTX-induced testicular damage.