Green tea polyphenol (-)-epigallocatechin gallate prevents oxidative damage on periventricular white matter of infantile rats with hydrocephalus

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Etus V., Altug T., Belce A., Ceylan S.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, cilt.200, sa.4, ss.203-209, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 200 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1620/tjem.200.203
  • Dergi Adı: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.203-209
  • Anahtar Kelimeler: (-)-epigallocatechin gallate, green tea, hydrocephalus, periventricular white matter, lipid peroxidation, ANTIOXIDANT CHEMISTRY, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, PEROXYL RADICALS, BRAIN, CATECHINS, ISCHEMIA, PRODUCTS, STRESS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Hydrocephalus causes damage to periventricular white matter at least in part through chronic ischemia. Emphasizing the periventricular ischemia/hypoxia in hydrocephalus, various authors indicated the secondary biochemical impairment and oxidative damage in experimentally induced and congenital hydrocephalic rat brain. (-)-Epigallocatechin gallate (EGCG), the main constituent of green tea polyphenols, has been shown to be of some protective value in various models of neurological injury as a free oxygen radical scavenger. In the present study the effects of EGCG were examined on the periventricular oxidative damage in experimental childhood-onset hydrocephalus. Hydrocephalus was induced in 3 weeks-old rat pups by kaolin injection into the cisterna magna. A single daily dose of 50 mg/kg of EGCG injected into the peritoneum of the rats for 15 days significantly reduced periventricular white matter malondialdehyde levels when compared to non-treated hydrocephalic animals. Our results indicate that EGCG may have a protective effect against periventricular white matter oxidative damage in hydrocephalus induced infantile rats. (C) 2003 Tohoku University Medical Press.