Research Information System
EANS2024, Sofija, Bulgaria, 13 - 17 October 2024, vol.4, pp.67
Background: Pediatric pituitary adenomas are rare lesions and account for approximately 3% of all supratentorial tumors in children. There is a paucity of reports on endoscopic transsphenoidal surgery in children. The aim of this study was to assess outcomes of endoscopic pediatric pituitary adenoma surgery at a high volume tertiary center. Methods: Between August 1997 and November 2023, a total of 4809 cases underwent endoscopic transsphenoidal surgery for pituitary adenoma at the Department of Neurosurgery and Pituitary Research Center of the Kocaeli University School of Medicine. Of these, 73 (1.5%) pediatric patients (26 males, 47 females) (age <18 years) with a pathological diagnosis of pituitary adenoma were retrospectively reviewed. Results: The mean age of patients was 15.5 2.3 years. Among the hormonesecreting adenomas, 19 (33.4%) were adrenocorticotrophic hormone secreting, 14 (24.5%) were growth hormone secreting, 19 (33.4%) were prolactin secreting, and 5 (8.7%) were both growth hormone-prolactin secreting. Gross total resection was achieved in 93.75% of nonfunctional tumors. Five sparsely granulated corticotroph tumors, 5 sparsely granulated somatotroph tumors, and 11 densely granulated lactotroph tumors were classified as aggressive histopathological subtypes. Conclusions: The characteristics of the pediatric population and the aggressiveness of the disease in this population pose considerable therapeutic challenges. To increase treatment success, current adjuvant therapies that are appropriate for the morphological and biological characteristics of the tumor are required.