The diagnostic importance of pathogenic variants and variant coexistence determined by NGS-based liquid biopsy approach in patients with lung adenocarcinoma

Çine, NACİ; Sen, Emin; Demir, Gulhan; Gokbayrak, Merve; Guzdolu, Eda; Sertdemir, NİLÜFER; Aydın, Duygu; Kurtaş, ÖMER; Reka, Seda; Sünnetçi Akkoyunlu, DENİZ; Eren Keskin, SEDA; Uygun, KAZIM; Çabuk, DEVRİM; Aksu, MAKSUT; Cantürk, NUH; Savlı, HAKAN

doi:10.1016/j.mcp.2022.101819

The diagnostic importance of pathogenic variants and variant coexistence determined by NGS-based liquid biopsy approach in patients with lung adenocarcinoma

Atıf İçin Kopyala

Çine N., Sen E. A., Demir G., Gokbayrak M., Guzdolu E., Sertdemir N., ...Daha Fazla

MOLECULAR AND CELLULAR PROBES, cilt.64, 2022 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 64
Basım Tarihi: 2022
Doi Numarası: 10.1016/j.mcp.2022.101819
Dergi Adı: MOLECULAR AND CELLULAR PROBES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Cell free DNA, Liquid biopsy, Lung adenocarsinoma, NGS, TP53, EGFR, MET, ALK, PIK3CA, MAP2K, CIRCULATING TUMOR DNA, P53 MUTATIONS, MUTAGENIC SIGNATURE, TOBACCO-SMOKE, K-RAS, CANCER, PATTERNS, LESSONS
Kocaeli Üniversitesi Adresli: Evet

Özet

Backround: Identification of driver mutations and rapid detection of genetic changes in lung cancer are critical in the management of the disease. Genetic structures of tumor tissues tend to change constantly and the possibility of emergence of new pathogenic variants that will create resistance to treatment. Liquid biopsy analysis has been one of the most effective approaches used to monitor and identify individual genetic changes.