SELECTIVE-INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION BY SYMPATHECTOMY IN RABBIT CAROTID-ARTERY RINGS INVITRO


Kars Z., Utkan T. , Sarıoğlu Y., Yaradanakul V.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, cilt.15, ss.35-40, 1993 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 15
  • Basım Tarihi: 1993
  • Dergi Adı: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Sayfa Sayısı: ss.35-40

Özet

The influence of cervical and periarterial sympathectomy on endothelium-dependent relaxation of the rabbit common carotid artery was studied in vitro. Noradrenaline, serotonin, acetylcholine and papaverine concentration-response curves of sympathectomized and control rabbit common carotid artery rings were recorded and analyzed and effects of endothelium removal were investigated. Endothelium-dependent relaxation was selectively and significantly inhibited in 3 weeks postsympathectomy arterial preparations. Alterations in acetylcholine receptors of endothelial cells, decrease in endothelium-derived relaxing factor synthesis, or desensitization of medial muscular cells to endothelium-derived relaxing factor are hypothetical causes of this phenomenon.