Evaluation of left and right ventricle by two-dimensional speckle tracking echocardiography in systemic sclerosis patients without overt cardiac disease

Karadag D., Sahin T., Tekeoglu S., Işik O., Yazici A., Eraldemir F. C., ...Daha Fazla

CLINICAL RHEUMATOLOGY, cilt.39, sa.1, ss.37-48, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s10067-019-04604-3
  • Dergi Adı: CLINICAL RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.37-48
  • Anahtar Kelimeler: Left ventricle, Right ventricle, Speckle tracking echocardiography, Systemic sclerosis, Systolic dysfunction, GLOBAL LONGITUDINAL STRAIN, EULAR SCLERODERMA TRIALS, DOPPLER-ECHOCARDIOGRAPHY, HEART INVOLVEMENT, AMERICAN-SOCIETY, FIBROSIS, GUIDELINES, RECOMMENDATIONS, CLASSIFICATION, ASSOCIATION
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background/objective The aim was to evaluate the left and right ventricular functions concurrently by two-dimensional speckle tracking echocardiography (STE) in systemic sclerosis (SSc) patients without overt cardiac disease. Methods A total of 47 patients with SSc and 36 age- and sex-matched controls were evaluated cross-sectionally. Two-dimensional STE was used to assess the longitudinal peak systolic strains (PSS) of both ventricles including apical long-axis (APLAX), apical four-chamber (4-CH), apical two-chamber (2-CH), and global longitudinal measurements. Any association of metabolic, cardiac, and inflammatory biomarkers with PSS was investigated. Results The longitudinal PSS of the left ventricle [APLAX, 4-CH, 2-CH and global] were significantly lower in SSc patients than controls (- 18.2 +/- 3.2 vs - 19.8 +/- 2.7% p = 0.02; - 17.8 +/- 3.5 vs. - 20.3 +/- 3.3% p = 0.001; - 18.6 +/- 3.1 vs. - 21.8 +/- 3% p < 0.001; - 17.5 +/- 5.7 vs. - 20.6 +/- 2.7% p = 0.003, respectively). No difference was found between the groups for right ventricular strains. The longitudinal PSS-4CH correlated positively with CRP and ESR (r = 0.349, p = 0.016; r = 0.356, p = 0.014, respectively) and negatively with serum Galectin-3 (r = - 0.362, p = 0.012). Global longitudinal PSS-left ventricle (LV) correlated positively with CRP and homocysteine (r = 0.297, p = 0.043; r = 0.313, p = 0.041, respectively) and negatively with serum Galectin-3 (r = -0.314, p = 0.041). After multivariable adjustment, CRP remained the only predictor of longitudinal PSS-4CH (95% CI 0.35, 0.70, p = 0.028) and global longitudinal PSS of left ventricle (95% CI 0.004, 0.22, p = 0.043). Conclusions Biventricular evaluation of patients with SSc by two dimensional STE revealed reduced left ventricular longitudinal strains, despite preserved right ventricular strain, and no diastolic dysfunction. In SSc without overt cardiac disease, global cardiac assessment with 2DSTE is a promising method which seems to contribute to the detection of patients without clinical findings.