D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model

Saridogan, Gokce; Aykac, Asli; CABADAK, HÜLYA; CERİT, CEM; Caliskan, Mecit; GÖREN, MEHMET

doi:10.1016/j.bbr.2015.07.050

D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model

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Saridogan G. E., Aykac A., CABADAK H., CERİT C., Caliskan M., GÖREN M. Z.

BEHAVIOURAL BRAIN RESEARCH, vol.293, pp.227-233, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 293
Publication Date: 2015
Doi Number: 10.1016/j.bbr.2015.07.050
Journal Name: BEHAVIOURAL BRAIN RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.227-233
Kocaeli University Affiliated: Yes

Abstract

D-cycloserine (DCS), an FDA approved anti-tuberculosis drug has extensively been studied for its cognitive enhancer effects in psychiatric disorders. DCS may enhance the effects of fear extinction trainings in animals during exposure therapy and hence we investigated the effects of DCS on distinct behavioral parameters in a predator odor stress model and tested the optimal duration for repeated daily administrations of the agent.