D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model


Saridogan G. E. , Aykac A., CABADAK H., CERİT C. , Caliskan M., GÖREN M. Z.

BEHAVIOURAL BRAIN RESEARCH, cilt.293, ss.227-233, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 293
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.bbr.2015.07.050
  • Dergi Adı: BEHAVIOURAL BRAIN RESEARCH
  • Sayfa Sayıları: ss.227-233

Özet

D-cycloserine (DCS), an FDA approved anti-tuberculosis drug has extensively been studied for its cognitive enhancer effects in psychiatric disorders. DCS may enhance the effects of fear extinction trainings in animals during exposure therapy and hence we investigated the effects of DCS on distinct behavioral parameters in a predator odor stress model and tested the optimal duration for repeated daily administrations of the agent.