D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model


Saridogan G. E., Aykac A., CABADAK H., CERİT C., Caliskan M., GÖREN M. Z.

BEHAVIOURAL BRAIN RESEARCH, vol.293, pp.227-233, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 293
  • Publication Date: 2015
  • Doi Number: 10.1016/j.bbr.2015.07.050
  • Journal Name: BEHAVIOURAL BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.227-233
  • Kocaeli University Affiliated: Yes

Abstract

D-cycloserine (DCS), an FDA approved anti-tuberculosis drug has extensively been studied for its cognitive enhancer effects in psychiatric disorders. DCS may enhance the effects of fear extinction trainings in animals during exposure therapy and hence we investigated the effects of DCS on distinct behavioral parameters in a predator odor stress model and tested the optimal duration for repeated daily administrations of the agent.