D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model

Saridogan, Gokce; Aykac, Asli; CABADAK, HÜLYA; CERİT, CEM; Caliskan, Mecit; GÖREN, MEHMET

doi:10.1016/j.bbr.2015.07.050

D-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model

Atıf İçin Kopyala

Saridogan G. E. , Aykac A., CABADAK H., CERİT C. , Caliskan M., GÖREN M. Z.

BEHAVIOURAL BRAIN RESEARCH, cilt.293, ss.227-233, 2015 (SCI İndekslerine Giren Dergi)

Cilt numarası: 293
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.bbr.2015.07.050
Dergi Adı: BEHAVIOURAL BRAIN RESEARCH
Sayfa Sayıları: ss.227-233

Özet

D-cycloserine (DCS), an FDA approved anti-tuberculosis drug has extensively been studied for its cognitive enhancer effects in psychiatric disorders. DCS may enhance the effects of fear extinction trainings in animals during exposure therapy and hence we investigated the effects of DCS on distinct behavioral parameters in a predator odor stress model and tested the optimal duration for repeated daily administrations of the agent.