Akademik Veri Yönetim Sistemi
BİLTEK-VIII International Symposium on Current Developments in Science, Technology and Social Sciences, Paris, Fransa, 24 Ekim 2023, ss.333-335
The method of fiber production from solution mixture is one of the simplest and most frequently used methods in today's industry (1). In fiber attraction in polymer solution by electrospinning method, polymer is electrically charged by using a high potential voltage, this polymer solution sent from the syringe tip flows towards the grounded target placed opposite the device. Thanks to this current, the polymer is scattered into very thin fibers, and thanks to this, fibers of the desired diameter level can be obtained. Nanofibers obtained according to the electrospinning method, the surface area is; the desired parameters such as porosity, structure and mechanical properties are obtained at the desired rates (2). In this study, benzalkonium chloride nanofibers, which are a quaternary ammonium salt (QAS) containing poly(lactic acid) (PLA)/poly (ethylene glycol) (PEG) polymers, were produced by electrospinning method. Since PLA is a fragile polymer due to its structure, PEG polymer was used as a plasticizer in this study (3). This is advantageous in environmentally conscious applications, as PLA is a biodegradable polymer. Quaternary ammonium salts are known for their antimicrobial and antibacterial activities. One of the main reasons for adding QAS to PLA nanofibers is to give the polymer antimicrobial properties. When integrated into the PLA, they can inhibit the growth of bacteria and other microorganisms. PLA nanofibers remain biodegradable even after the incorporation of quaternary ammonium salts. This property is especially valuable in applications such as wound dressings, textiles and air filtration, where the prevention of microbial growth is important. The characterization studies of the obtained nanofibers were carried out by Scanning Electron Microscopy (SEM), tensile and antibacterial tests. A significant average diameter increase is seen in the results obtained in the SEM. Yield strength, elongation at break and Young's modulus evaluations were made in the tensile test. According to the results, elongation in the rupture decreased with increasing concentration, while it increased at its maximum concentration. According to the results, elongation in the rupture decreased with increasing concentration, while it increased at its maximum concentration. according to the yield strength results, the value of the sample without salt addition was 0.38 MPa, while the minimum salt decreased to 0.28 MPa when added. When the salt concentration was increased gradually, 0.34 MPa and 0.32 MPa measurements were taken. The Young's modulus decreased with the minimum addition of salt, and the Young's modulus increased proportionally as the amount of salt increased. In the antibacterial activity test, the antibacterial activity of BCL-doped nanofibers was observed in Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial cultures. According to the antibacterial results, 100% antibacterial activity was observed in all salt ratios in bacterial cultures. This work has been supported by Kocaeli University Scientific Research Projects Coordination Unit undergrant number number FBA-2023-3169.