Dual stimuli-responsive chitosan grafted poly(NIPAM-co-AAc)/poly(vinyl alcohol) hydrogels for drug delivery applications

GÜNGÖR, AHMET; Demir, Didem; Bolgen, Nimet; Ozdemir, Tonguc; Genc, Rukan

doi:10.1080/00914037.2020.1765355

Dual stimuli-responsive chitosan grafted poly(NIPAM-co-AAc)/poly(vinyl alcohol) hydrogels for drug delivery applications

GÜNGÖR A., Demir D., Bolgen N., Ozdemir T., Genc R.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.70, sa.11, ss.810-819, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 70 Sayı: 11
Basım Tarihi: 2021
Doi Numarası: 10.1080/00914037.2020.1765355
Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
Sayfa Sayıları: ss.810-819
Kocaeli Üniversitesi Adresli: Hayır

Özet

Herein, we synthesized poly(vinyl alcohol) (PVA) decorated chitosan grafted poly(NIPAM-co-AAc) hydrogels through free-radical copolymerization. Increased PVA concentration revealed enhancement of temperature and pH sensitivity of the hydrogel by changing the porous structure and surface properties. Further,in vitrodrug delivery studies carried out with a model dye revealed a six-fold increased release of the content at pH 7.4 with respect to pH 4.4. This new combination of three component hydrogels could be effectively used as an alternative material in the development of stimuli triggered drug delivery systems that are stable at tissues and organs with a low pH environment.