Comparison of inflammatory indices, spleen size, and enthesis thickness during attack and attack-free periods in patients with Familial Mediterranean Fever

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Özaslan N. Z., Şahin N., Sönmez H. E.

33rd European Paediatric Rheumatology Congress, Belgrade, Sırbistan, 16 - 19 Eylül 2026, ss.180-181, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Belgrade
  • Basıldığı Ülke: Sırbistan
  • Sayfa Sayıları: ss.180-181
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Introduction Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent fever and serositis attacks, with persistent subclinical inflammation during attack-free periods. Increased spleen size, enthesis thickening, and alterations in inflammatory indices may reflect ongoing inflammation. Objectives To compare clinical findings, spleen size, enthesis thicknesses, and in flammatory indices in FMF patients during attack and attack-free periods. Methods This prospective study included 36 FMF patients evaluated during both attack and attack-free periods. Clinical, laboratory, and ultrasonograph ic findings were prospectively recorded. Disease activity was assessed using C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), systemic immune-inflammation index (SII), systemic inflammation re sponse index (SIRI), neutrophil-to-lymphocyte ratio (NLR), platelet-to lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), mono cyte-to-lymphocyte ratio (MLR), and platelet-to-neutrophil ratio (PNR). Spleen size and enthesis thicknesses were measured by ultrasonogra phy and compared between attack and attack-free periods. Results A total of 36 patients (21 females, 15 males) were included in the study. The median age was 11 years (5–17), median age at symptom onset was 5 years (1–13), and median age at diagnosis was 6.5 years (2–14). The median follow-up duration was 4.7 years (1–12.3). Regarding MEFV mu tations, 27 patients (75.0%) had exon 10 homozygous mutations and 9 patients (25%) had exon 10 heterozygous mutations. During attacks, all patients (100%) experienced fever, abdominal pain, and arthralgia, while 12 patients (33.3%) also had chest pain. Exercise-related leg pain was present in 25 patients (69.4%), anemia in 15 (41.7%), arthritis in 6 (16.7%), history of appendectomy in 4 (11.1%), and erysipelas-like erythema in 1 patient (2.8%). Eighteen patients (50%) were considered colchicine-resistant.The mean disease severity score was 3 (1–7) Conclusion Comparison of attack and attack-free periods in FMF patients showed significant increases in inflammatory markers, particularly CRP, ESR, and inflammatory indices (SII, SIRI, NLR, PLR, and LMR), as well as spleen size during attacks. However, no significant differences were observed in enthesis thicknesses between the two periods. These findings suggest that, in addition to acute phase reactants and inflammatory indices, spleen size may also reflect disease activity and acute inflammation. Disclosure of interest None declared.