Esophageal smooth muscle reactivity is impaired in chronic reflux esophagitis by both receptor- and nonreceptor-mediated mechanisms

Tuğtepe, Halil; Tugay, Melih; Bozkurt, Suheyla; Yildiz, FÜRÜZAN; Utkan, TİJEN; Yegen, Berrak; Dagli, Tolga

doi:10.1016/j.jpedsurg.2006.12.048

Esophageal smooth muscle reactivity is impaired in chronic reflux esophagitis by both receptor- and nonreceptor-mediated mechanisms

Tuğtepe H., Tugay M., Bozkurt S., Yildiz F., Utkan T., Yegen B. C., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.42, pp.641-646, 2007 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 42
Publication Date: 2007
Doi Number: 10.1016/j.jpedsurg.2006.12.048
Journal Name: JOURNAL OF PEDIATRIC SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.641-646
Keywords: gastroesophageal reflux, smooth muscle, carbachol, serotonin, in vitro, esophagus, GASTROESOPHAGEAL-REFLUX, MOTOR ABNORMALITIES, CIRCULAR MUSCLE, DISEASE, RAT, MOTILITY, PH, FUNDOPLICATION, DYSFUNCTION, RELAXATION
Kocaeli University Affiliated: Yes

Abstract

Aim: Esophagitis is associated with an impaired esophageal peristalsis. A few studies have been aimed at understanding the pathophysiology of abnormal peristaltic activity. The mechanism of impaired esophageal smooth muscle reactivity in the chronic gastroesophageal reflux (GER) model is investigated in vitro for the first time.