Gabapentin, A GABA analogue, enhances cognitive performance in mice


Celikyurt I. K. , MUTLU O. , ULAK G. , Akar F. , Erden F.

NEUROSCIENCE LETTERS, cilt.492, ss.124-128, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 492 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.neulet.2011.01.072
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Sayfa Sayısı: ss.124-128

Özet

Gabapentin is one of the new antiepileptic drugs (AEDs) launched recently. The advantage of new AEDs includes newer mechanism of action, broad spectrum of antiseizure effects, lesser drug interactions and fewer side effects. Gabapentin (GBP) a GABA analogue, is efficacious in several neurological and psychiatric conditions and it is conventionally used in the treatment of partial epilepsies. In this study, we aimed to evaluate the effects of GBP on learning and memory processes of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tests. GBP (5 and 10 mg/kg, i.p.) was administered on the probe trial of MWM and on the acquisation session of PA and mEPM tests. In the MWM test, GBP (10 mg/kg) significantly increased the time spent in target quadrant and GBP (5 and 10 mg/kg) significantly decreased the distance to platform compared to control group. In the mEPM test, GBP (5 and 10 mg/kg) significantly decreased the transfer latency compared to control group on the second day and in the PA test, GBP (5 and 10 mg/kg) significantly prolonged retention latency compared to control group. Our results indicate that GBP has improving effects on spatial and emotional cognitive performance of naive mice in MWM. PA and mEPM tasks. (C) 2011 Elsevier Ireland Ltd. All rights reserved.