Telomeric DNA: Marker for human prostate cancer development?

Ozen M. , Imam S., Datar R., Multani A., Narayanan R., Chung L., ...More

PROSTATE, vol.36, no.4, pp.264-271, 1998 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 1998
  • Title of Journal : PROSTATE
  • Page Numbers: pp.264-271
  • Keywords: telomere, ribonucleoprotein, telomerase, prostate cancer, programmed cell death, TRAP assay, CHROMOSOME END ASSOCIATIONS, PROGRAMMED CELL-DEATH, APOPTOSIS, INDUCTION, PROTEIN, BCL-2, PC-3


BACKGROUND. Telomeres that protect chromosomes at both ends are shortened with each somatic cell division through replication-dependent sequence loss at DNA termini. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Due largely to reactivation/upregulation of telomerase, a ribonucleoprotein that adds nucleotide sequences onto chromosome ends, cancer cells become immortal and neoplastically transformed.