Telomeric DNA: Marker for human prostate cancer development?

Ozen M., Imam S., Datar R., Multani A., Narayanan R., Chung L., ...More

PROSTATE, vol.36, no.4, pp.264-271, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 1998
  • Journal Name: PROSTATE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.264-271
  • Keywords: telomere, ribonucleoprotein, telomerase, prostate cancer, programmed cell death, TRAP assay, CHROMOSOME END ASSOCIATIONS, PROGRAMMED CELL-DEATH, APOPTOSIS, INDUCTION, PROTEIN, BCL-2, PC-3
  • Kocaeli University Affiliated: Yes

Abstract

BACKGROUND. Telomeres that protect chromosomes at both ends are shortened with each somatic cell division through replication-dependent sequence loss at DNA termini. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Due largely to reactivation/upregulation of telomerase, a ribonucleoprotein that adds nucleotide sequences onto chromosome ends, cancer cells become immortal and neoplastically transformed.