Microwave Assisted Synthesis of 2,3-Dihydro-4H- furo[2,3-d]pyrido[1,2-a]pyrimidin-4-ones and furo[2,3-d]pyrido[1,2-a]pyrimidin-4-one

Yalduz S., YILMAZ M.

CHEMISTRYSELECT, cilt.8, sa.10, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 10
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/slct.202204260
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Anahtar Kelimeler: Cyclization, Dihydrofurans, Heterocycles, Manganese(III) acetate, Microwave chemistry, FLUORINATED 1,3-DICARBONYL COMPOUNDS, ACETATE MEDIATED SYNTHESIS, MANGANESE(III) ACETATE, RADICAL CYCLIZATION, DERIVATIVES, 3-OXOPROPANENITRILES, HETEROCYCLES, DIHYDROFURANS, 2-THIENYL
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Kocaeli University, Kabaoglu, 41380, In this work, furo[2,3-d]pyrido[1,2-a]pyrimidin-4-ones were obtained by microwave assisted radical cyclizations of 2-hydroxy-4H-pirido[1,2-a]pirimidin-4-ones with conjugated alkenes and phenylacetylene via Mn(OAc)(3.) Conventional heating and microwave irradiated reaction types were compared using parameters like temperature, time and molar ratios to determine best reaction condition. Obtained compounds were purified by chromatographic methods and characterized by spectroscopic techniques (H-1 NMR, C-13 NMR, HRMS, FTIR). Also, to determine the exact configuration and regioselectivity of isolated compounds, XRD analysis were performed.