The oxidation of 3-hydroxy-3-methyl-Delta(4)-steroids by chromium trioxide


Uyanik C. , Hanson J., Hitchcock P.

JOURNAL OF CHEMICAL RESEARCH-S, sa.12, ss.795-797, 2003 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: Konu: 12
  • Basım Tarihi: 2003
  • Dergi Adı: JOURNAL OF CHEMICAL RESEARCH-S
  • Sayfa Sayıları: ss.795-797

Özet

Oxidation of the allylic tertiary alcohols of 3-hydroxy-3-methyl-Delta(4)-steroids by chromium trioxide in sulfuric acid leads to C-C bond fission together with the formation of a 3-methylestra-1,3,5(10)-triene from a 19-nor steroid and a 3beta,4beta-epoxy-5beta-hydroxy compound from an androstane; the structure of the hydroxy-epoxide was established by X-ray crystallography.