Chitosan/bacterial cellulose/polyacrylate hydrogel films loaded cinnamaldehyde oil as potential bioactive wound care materials: synthesis, characterization, and biological evaluation
Colloid and Polymer Science, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s00396-026-05644-3
- Dergi Adı: Colloid and Polymer Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC
- Anahtar Kelimeler: Antibacterial activity, Bacterial cellulose, Chitosan, Controlled release, Hydrogel films
- Kocaeli Üniversitesi Adresli: Evet
Özet
Cinnamaldehyde oil (CO) is a potent natural antimicrobial agent; however, its volatility and poor aqueous stability limit direct biomedical application. Encapsulation within biopolymer-based gels offers a promising strategy for controlled delivery in wound care. Herein, bioactive chitosan/bacterial cellulose/polyacrylate (CS/BC/PA) gel films were fabricated via ionic crosslinking with sodium tripolyphosphate. The films were characterized using FTIR, SEM, XRD, and TGA, and evaluated for swelling, mechanical properties, in vitro degradation, CO loading/release, antibacterial activity, and cytocompatibility. Based on the obtained results the gels exhibited high swelling (> 400%) and tunable degradation, with weight loss decreasing from 26.37 ± 1.78% to 6.25 ± 0.95% over 15 days. Mechanical strength improved from 1.24 ± 0.16 to 8.42 ± 0.91 kPa with increased crosslinking. CO loading efficiency reached 84.53 ± 2.43%, with sustained release up to 64.85 ± 3.24% at 420 min, following Korsmeyer–Peppas kinetics (R² = 0.922, n = 0.57). Antibacterial activity showed inhibition zones of 15.65 ± 1.32 mm and 17.90 ± 1.54 mm against S. aureus and K. pneumoniae, respectively, while cell viability remained > 75%. In conclusion, the developed BGFs demonstrate controlled release, antibacterial efficacy, and cytocompatibility, indicating potential as multifunctional wound dressing materials, warranting further biological validation.