Retinoid metabolism in endometriosis

Cakiroglu Y., Confino R., Pavone M. E.

JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS, cilt.9, sa.4, ss.232-238, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5301/jeppd.5000309
  • Dergi Adı: JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE
  • Sayfa Sayıları: ss.232-238
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Endometriosis is an estrogen-dependent disease in which progesterone resistance and inflammation have been found to be major mechanisms responsible for its development and progression. When compared to eutopic endometrium, key molecules have been found to be differentially expressed, which contribute to these mechanisms. One pathway that is aberrant in endometriotic tissue when compared to eutopic endometrium is the retinoic acid signaling pathway. This review focuses on the role of the retinoid signaling pathway in endometriosis and summarizes evidence that supports the use of retinoid compounds for the stimulation of pro-apoptotic activity in these cells.