Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens
INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.49, pp.1561-1567, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 49
- Publication Date: 2017
- Doi Number: 10.1007/s11255-017-1640-9
- Journal Name: INTERNATIONAL UROLOGY AND NEPHROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1561-1567
- Keywords: Aripiprazole, Clozapine, Haloperidol, Organ bath, SEXUAL DYSFUNCTION, ANTIPSYCHOTIC-DRUGS, COPULATORY-BEHAVIOR, RAT, SCHIZOPHRENIA, FLUOXETINE, EJACULATION, SEROTONIN, ANTIDEPRESSANT, CONTRACTILITY
- Kocaeli University Affiliated: Yes
Abstract
Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens.