Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens
INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.49, ss.1561-1567, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49
- Basım Tarihi: 2017
- Doi Numarası: 10.1007/s11255-017-1640-9
- Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1561-1567
- Anahtar Kelimeler: Aripiprazole, Clozapine, Haloperidol, Organ bath, SEXUAL DYSFUNCTION, ANTIPSYCHOTIC-DRUGS, COPULATORY-BEHAVIOR, RAT, SCHIZOPHRENIA, FLUOXETINE, EJACULATION, SEROTONIN, ANTIDEPRESSANT, CONTRACTILITY
- Kocaeli Üniversitesi Adresli: Evet
Özet
Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens.