Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens

Tanyeri M. H. , Buyukokuroglu M. E. , Tanyeri P., Mutlu O. , Akar F. , Ulak G. , et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.49, ss.1561-1567, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 49
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s11255-017-1640-9
  • Sayfa Sayısı: ss.1561-1567


Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens.