Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens

Tanyeri M. H., Buyukokuroglu M. E., Tanyeri P., Mutlu O., Akar F., Ulak G., ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.49, pp.1561-1567, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49
  • Publication Date: 2017
  • Doi Number: 10.1007/s11255-017-1640-9
  • Journal Name: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1561-1567
  • Keywords: Aripiprazole, Clozapine, Haloperidol, Organ bath, SEXUAL DYSFUNCTION, ANTIPSYCHOTIC-DRUGS, COPULATORY-BEHAVIOR, RAT, SCHIZOPHRENIA, FLUOXETINE, EJACULATION, SEROTONIN, ANTIDEPRESSANT, CONTRACTILITY
  • Kocaeli University Affiliated: Yes

Abstract

Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens.