Detection of SARS-CoV-2 N501Y mutation among SARS-CoV-2 variants of concern circulating in Northern Cyprus

Tuncel G., Ergoren M. C., Baddal B., Tulay P., Ozverel C. S., Guler E., ...Daha Fazla

FUTURE VIROLOGY, cilt.17, ss.523-528, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2022
  • Doi Numarası: 10.2217/fvl-2021-0273
  • Dergi Adı: FUTURE VIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.523-528
  • Anahtar Kelimeler: B, 1, 1, 7, B, 1, 351, COVID-19, N5017Y, P, 1, SARS-CoV-2, variants of concern
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Aim: SARS-CoV-2 variants of concern (VOCs) carry signature mutations particularly in the spike protein. Most VOCs lineages that carry N501Y substitution have been reported to evade viral diagnostic tests and have impact on vaccine effectiveness. Therefore, monitoring the circulating variants represents a major requirement for a public health response worldwide. We aimed to investigate the prevalence of N501Y bearing SARS-CoV-2 samples in Northern Cyprus. Materials & methods: Reverse transcription quantitative PCR technique was used to identify N501Y mutation from 658 samples. Results: Our results indicate that the proportion of N501Y-bearing lineages increased significantly from January through May 2021 (45.2-75.5%) in the region. Conclusion: These results indicate that VOCs are dominant lineages in the country and highlight an alarming situation which require strict governmental measures to minimize COVID-19 morbidity and mortality.