Mean platelet volume and platelet distribution width levels in discoid lupus erythematosus patients: A case-control study

Journal of Surgery and Medicine, cilt.3, sa.8, ss.561-563, 2019 (Hakemli Dergi)

Aim: Platelets (PLT) play an important role in inflammatory reactions and immune responses. This study aims to evaluate PLT

and PLT parameters in patients with discoid lupus erythematosus (DLE), which is characterized by inflammation.

Methods: In this case-control study, a total of 125 participants, consisting of 60 DLE patients and 65 healthy controls, were

selected to participate. PLT, platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of

neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR) were studied retrospectively in both groups.

Results: The mean age of the patient group was 47.30 (15.14) years, and the mean age of the control group was 38.08 (13.33)

years. There were no statistically significant differences between the PLT, PDW, MPV, PCT, NLR, and PLR levels in DLE

patients and healthy controls (P=0.365, P=0.988, P=0.160, P=0.851, P=0.898, and P=0.887, respectively).

Conclusion: To the best of our knowledge, there are no reports on PLT, PDW, PCT, NLR, PLR, and MPV in patients with

DLE. We did not find a significant difference in the DLE group. PLT parameters are low-cost tests that can be used to define

inflammation levels in inflammatory diseases. Further prospective studies on this subject will contribute to this work.