Adipose-Derived Stem Cells Improve Survival of Random Pattern Cutaneous Flaps in Radiation Damaged Skin

Hasdemır M., Agır H., Eren G. G., Aksu M. G., Alagöz M. Ş., Duruksu G., ...Daha Fazla

JOURNAL OF CRANIOFACIAL SURGERY, cilt.26, ss.1450-1455, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/scs.0000000000001852
  • Dergi Adı: JOURNAL OF CRANIOFACIAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1450-1455
  • Anahtar Kelimeler: Adipose-derived stem cell, flap survival, radiation injury, random pattern dorsal flap, RAT MODEL, INJURY, TISSUE, TRANSPLANT, VIABILITY, THERAPY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background: Tissue ischemia and necrosis following surgery after radiotherapy on the skin and subcutaneous tissue are well known to all reconstructive surgeons. Nevertheless, there has been no report so far on local effects of adipose-derived stem cells (ADSCs) on random flap survival elevated in an irradiated rat dorsum. In this experimental study, we aimed to identify the effect of adipose tissue-derived stem cell injection on random flap survival in irradiated tissues.