Adipose-Derived Stem Cells Improve Survival of Random Pattern Cutaneous Flaps in Radiation Damaged Skin

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Hasdemır M., Agır H., Eren G. G., Aksu M. G., Alagöz M. Ş., Duruksu G., ...More

JOURNAL OF CRANIOFACIAL SURGERY, vol.26, pp.1450-1455, 2015 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 26
• Publication Date: 2015
• Doi Number: 10.1097/scs.0000000000001852
• Journal Name: JOURNAL OF CRANIOFACIAL SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1450-1455
• Keywords: Adipose-derived stem cell, flap survival, radiation injury, random pattern dorsal flap, RAT MODEL, INJURY, TISSUE, TRANSPLANT, VIABILITY, THERAPY
• Kocaeli University Affiliated: Yes

Abstract

Background: Tissue ischemia and necrosis following surgery after radiotherapy on the skin and subcutaneous tissue are well known to all reconstructive surgeons. Nevertheless, there has been no report so far on local effects of adipose-derived stem cells (ADSCs) on random flap survival elevated in an irradiated rat dorsum. In this experimental study, we aimed to identify the effect of adipose tissue-derived stem cell injection on random flap survival in irradiated tissues.