Bifunctional catalysis of ester hydrolysis: novel hydrolytic enzyme models based on xanthene framework

Saki N., Akkaya E.

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, vol.219, no.2, pp.227-232, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 219 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1016/j.molcata.2004.06.004
  • Journal Name: JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.227-232
  • Keywords: biomimetic catalysts, artificial enzymes, enzyme mimics, enzyme models, supramolecular chemistry, CONVERGENT FUNCTIONAL-GROUPS, PHOSPHODIESTER TRANSESTERIFICATION ACTIVITY, ARTIFICIAL ENZYMES, MOLECULAR CLEFTS, DNA, CHEMISTRY, COMPLEX, BINDING
  • Kocaeli University Affiliated: Yes

Abstract

Xanthene framework has been derivatized to carry adjacent hydrolytically active units. A comparison was made between the hydrolytic activities of the Zn(II) complexes of xanthene derivatives with two cyclen (5), one cyclen and one imidazole (7), and one cyclen and one hydroxymethyl (12) units. The cyclen-imidazole carrying derivative showed the largest rate acceleration (5700-fold), demonstrating the efficiency of multifunctional catalysis. (C) 2004 Elsevier B.V. All rights reserved.