Akademik Veri Yönetim Sistemi
7. Uluslararası Haliç Multidisipliner Bilimsel Araştırmalar Kongresi, İstanbul, Türkiye, 23 - 25 Ocak 2024, ss.1489-1496
Today, nanofibers produced by electrospinning meet all the requirements of modern wound dressings. Poly(lactic acid) (PLA) is frequently used in medical fields because it is a biocompatible and biodegradable polymer. PLA is brittle due to its natural structure; in studies, it is preferred to be mixed with plasticizers. In this study, PLA was used by mixing with poly(ethylene glycol) (PEG) (80/20 w/w). Solutions were prepared by adding tetra-nbutylammonium hydrogen sulfate (THS) quaternary ammonium salt into PLA20PEG at rates of 3% and 5%, depending on the total solid amount. It was aimed to use the nanofibers, which were successfully obtained from solutions prepared using the electrospinning method, as wound dressings with antibacterial effects. Characterization studies of nanofibers were carried out by Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric analysis (TGA), and antibacterial and cytotoxicity analyses. Characteristic peaks of THS salt were observed in all nanofibers by FTIR test. It was observed that the thermal properties of the nanofibers increased with the addition of salt. While Tmax2 temperature was not observed in pure PLAPEG nanofiber, temperature values of 214.57 oC and 221.28 oC were noticed in 3% and 5% salt-doped nanofibers, respectively. It was reported that at the end of the 24th hour, 99.99% antibacterial activity was observed against E.coli and S.aureus bacteria in the nanofiber with only 5% salt added. It was also stated that at the end of the 24th hour, pure PLA-PEG, 3%, and 5% THS salt-doped nanofibers exhibited 93%, 129%, and 124% fibroblast cell viability, respectively. These results confirmed that the obtained nanofibers could be used as wound dressings. However, it is planned to perform advanced analyses such as SEM, nanofiber diameter measurement, liquid absorption, and drying time.