Monophasic pericardial synovial sarcoma in a turkish female patient: a very rare case with cyto-histopathological findings


YAPRAK BAYRAK B., VURAL Ç., SEZER H. F., ELİÇORA A., Busra Y.

Journal of Cardiothoracic Surgery, vol.18, no.1, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1186/s13019-023-02216-2
  • Journal Name: Journal of Cardiothoracic Surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Keywords: Cytopathology, Histopathology, Pericardial synovial sarcoma, Soft tissue neoplasm, MAGNETIC-RESONANCE
  • Kocaeli University Affiliated: Yes

Abstract

Background: The aim was to present a 35-year-old female patient with diagnosis of monophasic primary pericardial synovial sarcoma (PSS) with cytopathological findings. Case Presentation: The case with back pain, palpitation and weakness, was diagnosed with pericardial effusion and suspicious mass adjacent to right heart in ultrasonography. Computerized tomography showed mass 12 × 11 × 6.5 cm in size, located in right mid-anterior pericardial area, with heterogeneous internal structure, heterogeneously contrasting right heart and prominent pressure on superior vena cava. Cytopathology of pericardial effusion showed monotonous cells with oval-spindle vesicular nuclei, less amphophilic cytoplasm, evenly distributed chromatin and inconspicuous nucleoli. The pericardial mass was resected incompletely, spindle cell mesenchymal tumor with hypercellular fascicular structure and with infiltrative margins, containing a small amount of loose myxoid stroma, occasionally necrotic areas was observed histopathologically. Immunohistochemical positive reaction was for vimentin, Bcl-2, TLE-1. Accordingly, the case was diagnosed with monophasic PSS. Conclusions: This case of monophasic primary PSS was an extremely rare malignancy diagnosed with the cytopathological findings.