Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.

Schaefer, Arne; Bochenek, Gregor; Jochens, Arne; Ellinghaus, David; Dommisch, Henrik; Guezeldemir-Akcakanat, ESRA; Graetz, Christian; Harks, Inga; Jockel-Schneider, Yvonne; Weinspach, Knut; Meyle, Joerg; Eickholz, Peter; Linden, Gerry; Cine, NACİ; Nohutcu, Rahime; Weiss, Ervin; Houri-Haddad, Yael; Iraqi, Fuad; Folwaczny, Mathias; Noack, Barbara; Strauch, Konstantin; Gieger, Christian; Waldenberger, Melanie; Peters, Annette; Wijmenga, Cisca; Yilmaz, Engin; Lieb, Wolfgang; Rosenstiel, Philip; Doerfer, Christof; Bruckmann, Corinna; Erdmann, Jeannette; Koenig, Inke; Jepsen, Soren; Loos, Bruno; Schreiber, Stefan

doi:10.1161/circgenetics.114.000554

Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.

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Schaefer A. S., Bochenek G., Jochens A., Ellinghaus D., Dommisch H., Guezeldemir-Akcakanat E., ...More

Circulation. Cardiovascular genetics, vol.8, no.1, pp.159-67, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 8 Issue: 1
Publication Date: 2015
Doi Number: 10.1161/circgenetics.114.000554
Journal Name: Circulation. Cardiovascular genetics
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.159-67
Keywords: coronary artery disease, genetic association studies, periodontitis, plasminogen, GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCUS, TGF-BETA, ACTIVATION, ATHEROSCLEROSIS, INFLAMMATION, REPLICATION, 9P21.3, FORMS
Kocaeli University Affiliated: Yes

Abstract

Background-Genetic studies demonstrated the presence of risk alleles in the genes ANRIL and CAMTA1/VAMP3 that are shared between coronary artery disease (CAD) and periodontitis. We aimed to identify further shared genetic risk factors to better understand conjoint disease mechanisms.