Doxorubicin for prevention of epineurial fibrosis in a rat sciatic nerve model: outcome based on gross postsurgical, histopathological, and ultrastructural findings Laboratory investigation

Albayrak B. S., İSMAİLOĞLU Ö., Ilbay K., Yaka U., TANRIÖVER G., Gorgulu A., ...More

JOURNAL OF NEUROSURGERY-SPINE, vol.12, no.3, pp.327-333, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.3171/2009.9.spine09407
  • Journal Name: JOURNAL OF NEUROSURGERY-SPINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.327-333
  • Keywords: doxorubicin, epineural fibrosis, sciatic nerve, rat, RETROGRADE AXOPLASMIC-TRANSPORT, PERIPHERAL-NERVE, INDUCED INHIBITION, ADJUVANT CHEMOTHERAPY, COLLAGEN BIOSYNTHESIS, SCAR FORMATION, MITOMYCIN-C, MEDIAN NERVE, ADRIAMYCIN, SURGERY
  • Kocaeli University Affiliated: Yes

Abstract

Object. Epineural fibrosis may complicate peripheral nerve surgeries and currently is considered as one of the main factors responsible for failed surgeries. The authors investigated the postoperative antiscarring effects of topically applied doxorubicin (DXR) on rat sciatic nerves.