The Clinical Efficacy of Epoetin Alfa and Darbepoetin Alfa in Patients with Low-Risk or Intermediate-1-Risk Myelodysplastic Syndrome: Retrospective Multi-center Real-Life Study


Ak M. A. , Sahip B., GEDÜK A. , Ucar M. A. , Kale H., Hacibekiroglu T., ...More

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1007/s12288-021-01458-1
  • Title of Journal : INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

Abstract

This study aimed to evaluate the clinical efficacy of epoetin alfa and darbepoetin alfa in patients with myelodysplastic syndromes (MDS) in the real-life setting. A total of 204 patients with low-risk or intermediate-1-risk MDS who received epoetin alfa or darbepoetin alfa were included. Hemoglobin levels and transfusion need were recorded before and during 12-month treatment. Hemoglobin levels were significantly higher at each follow up visit when compared to baseline levels in both epoetin alfa (mean +/- SD 8.68 +/- 1.0 g/dL at baseline vs. 9.83 +/- 1.45, 9.99 +/- 1.55, 10.24 +/- 1.77 and 10.2 +/- 1.5 g/dL, respectively) and darbepoetin alfa (8.83 +/- 1.09 g/dL at baseline vs. 9.62 +/- 1.37, 9.78 +/- 1.49, 9.9 +/- 1.39 and 10.1 +/- 1.5 g/dL, respectively) groups (p < 0.001 for each). Transfusion need significantly decreased from baseline at each study visit in the epoetin alfa group (p < 0.001) and only at the 12th month visit (p < 0.001) in the darbepoetin alfa group. Hemoglobin levels or transfusion need was similar between treatment groups. Overall, 12-month response rate was 58.1% for epoetin alfa and 41.9% for darbepoetin alfa, with no significant difference between treatment groups, whereas higher response rate was noted within the first three months (62.7%) compared to next 9 months (ranged 44.4-60%) of treatment in the epoetin alfa group (p ranged 0.002 to < 0.001). This real-life retrospective study revealed similar efficacy of epoetin alfa and darbepoetin alfa among low risk or intermediate-1 risk MDS patients with no difference in treatment response between treatment groups, whereas a likelihood of earlier treatment response in the epoetin alfa group.