Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP

KORKMAZ O. T., ARKAN S., Oncu-Kaya E. M., ATEŞ N., Tuncel N.

NEUROSCIENCE LETTERS, cilt.765, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 765
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.neulet.2021.136268
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Absence epilepsy, Vasoactive intestinal peptide, GABA, Glutamate, Spike wave discharges, Somatosensory cortex, CYCLASE-ACTIVATING POLYPEPTIDE, SPIKE-WAVE DISCHARGES, THALAMOCORTICAL NEURONS, SUPRACHIASMATIC NUCLEUS, SYNAPTIC-TRANSMISSION, ANIMAL-MODEL, WAG/RIJ RAT, RECEPTORS, EPILEPSY, INTERNEURONS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Absence epilepsy is classified as a childhood generalized epilepsy syndrome with distinctive electroencephalographic patterns. The Wistar Albino Glaxo originating from Rijswijk (WAG/Rij) strain is a very well validated animal model of absence epilepsy that also shows behavioral deficits. In addition to the gastrointestinal system, VIP is highly expressed throughout numerous brain regions, and it plays crucial roles as a neurotransmitter and as a neuromodulatory, neurotrophic and neuroprotective factor in both the central and peripheral nervous systems.