Impact of COVID-19 pneumonia on interstitial lung disease: semi-quantitative evaluation with computed tomography

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Doğan S., Güldiken G. S., Alpaslan B., Barış S., Doğan N. Ö.

EUROPEAN RADIOLOGY, cilt.33, sa.7, ss.4758-4766, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 7
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00330-023-09441-2
  • Dergi Adı: EUROPEAN RADIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.4758-4766
  • Anahtar Kelimeler: COVID-19, Multidetector computed tomography, Fibrosis, Interstitial lung disease, Pneumonia, IDIOPATHIC PULMONARY-FIBROSIS, FLEISCHNER-SOCIETY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

ObjectivesTo evaluate the CT scores and fibrotic pattern changes in interstitial lung disease (ILD) patients, with and without previous COVID-19 pneumonia.MethodsPatients with ILD (idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated ILD (CTD-ILD)) were retrospectively enrolled in the study which consisted of patients who had COVID-19 pneumonia while the control group had not. All patients had two CT scans, initial and follow-up, which were evaluated semi-quantitatively for severity, extent, and total CT scores, fibrosis patterns, and traction bronchiectasis.ResultsA total of 102 patients (pneumonia group n = 48; control group n = 54) were enrolled in the study. For both groups, baseline characteristics were similar and CT scores were increased. While there was a 4.5 +/- 4.6 point change in the total CT score of the COVID-19 group, there was a 1.2 +/- 2.7 point change in the control group (p < 0.001). In the IPF subgroup, the change in total CT score was 7.0 points (95% CI: 4.1 to 9.9) in the COVID-19 group and 2.1 points (95% CI: 0.8 to 3.4) in the control group. Seven patients (14.6%) in the COVID-19 group progressed to a higher fibrosis pattern, but none in the control group.ConclusionsSemi-quantitative chest CT scores in ILD patients demonstrated a significant increase after having COVID-19 pneumonia compared to ILD patients who had not had COVID-19 pneumonia. The increase in CT scores was more prominent in the IPF subgroup. There was also a worsening in the fibrosis pattern in the COVID-19 group.