PURPOSE. To investigate the effect of accelerated aging on surface properties of glazed CAD/CAM resin blocks using a 2D surface profilometer and a 3D non-contact optical profilometer. MATERIALS AND METHODS. Three types of CAD/CAM resin restorative materials, LAVA Ultimate (3M ESPE, St Paul, MN, USA), VITA Enamic (Vita Zahnfabrik H. Rauter, Bad Sackingen, Germany), and Cerasmart (GC Corparation, Tokyo, Japan) were used for this study. CAD/CAM blocks were cut in 3-mm thickness slabs and divided into three groups; Group 1: control group (specimens polished with 600 grit SCI paper); Group 2: specimens sandblasted, silanized, and glazed with Optiglaze Color (GC); Group 3: glazed specimens subjected to 5000 thermocycles (n=15). The surface roughness (R-a and R-z) was evaluated using a profilometer and a 3D scanning instrument. Data were analyzed using twoway ANOVA and Tukey's post-hoc test (P<.05). RESULTS. LAVA, VITA, and Cerasmart exhibited statistically similar R-a and R-z values for each group (P>.05). For VITA and Cerasmart, the specimens in Group 1 exhibited significantly higher R-a values than Group 2 (P<.05). Group 1 (0.502 R-a), Group 2 (0.384 R-a), and Group 3 (0.431 R-a) exhibited statistically similar R-a values for LAVA (P=.062). After 5000 thermocycles, surface roughness values did not change significantly for glazed LAVA, VITA, and Cerasmart (P>.05). CONCLUSION. Glaze material Optiglaze Color makes CAD/CAM resin surfaces smooth and glazed CAD/CAM surfaces seem resistant to deterioration under 5000 thermocycles.