Zaprinast and rolipram enhances spatial and emotional memory in the elevated plus maze and passive avoidance tests and diminishes exploratory activity in naive mice.

Akar, FÜRÜZAN; MUTLU, OĞUZ; Komsuoglu Celikyurt, FERİDE; ULAK, GÜNER; Erden, BEKİR; BEKTAŞ, Emine; TANYERİ, Pelin

doi:10.12659/msmbr.891149

Zaprinast and rolipram enhances spatial and emotional memory in the elevated plus maze and passive avoidance tests and diminishes exploratory activity in naive mice.

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Akar F., MUTLU O., Komsuoglu Celikyurt I., ULAK G., Erden F., BEKTAŞ E., ...More

Medical science monitor basic research, vol.20, pp.105-11, 2014 (Scopus)

Publication Type: Article / Article
Volume: 20
Publication Date: 2014
Doi Number: 10.12659/msmbr.891149
Journal Name: Medical science monitor basic research
Journal Indexes: Scopus
Page Numbers: pp.105-11
Keywords: Behavior, Animal, Memory, Mice
Kocaeli University Affiliated: Yes

Abstract

Background: Phosphodiesterase (PDE) inhibitors in the central nervous system have been shown to stimulate neuronal functions and increase neurogenesis in Alzheimer disease (AD) patients.