Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections

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Yildirim F. S., SAYAN M.

VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL, vol.28, no.2, pp.72-78, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.4274/vhd.galenos.2022.2022-3-1
  • Journal Name: VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.72-78
  • Keywords: Human immunodeficiency virus, hepatitis B virus, hepatitis C virus, co-infection, RISK-FACTORS, HIV-INFECTION, ANTIRETROVIRAL THERAPY, GLOBAL EPIDEMIOLOGY, VIRAL-HEPATITIS, HOMOSEXUAL-MEN, CENTRAL-ASIA, T-CELLS, COINFECTION, PREVALENCE
  • Kocaeli University Affiliated: Yes

Abstract

Objectives: Viral hepatitis and human immunodeficiency virus (HIV) infections are still significant causes of morbidity and mortality. This study investigatedaimed to investigate the effect of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on HIV infection, investigate the epidemiological characteristics of co-infected patients and thus help identify risk factors for co -infection, evaluate the results and clinical information, and shape the treatment of patients.Materials and Methods: This descriptive, cross-sectional study from January 2013 to July 2021 was conducted carried out on 758 patients, including 502 infected with HIV, 196 co-infected with HBV/HCV, and 60 co-infected with HCV/HIV. Comparison between groups in terms of categorical characteristics was analyzed with the Pearson chi-square test or Fisher-Freeman-Halton test. The changes in HIV infection in the presence of co-infections were examined with the multivariate multinomial logistic regression model.Results: We found differences in our HIV-infected patients co -infected with HBV or HCV in gender, nationality, transmission routes, HIV viral load, and CD+4 T-cell count (p<0.001). There was no difference between the groups regarding age, opportunistic infection status, and malignancy status.Conclusion: Our findings indicate that HBV and HCV may affect HIV infection infections. Our approach can focus on these points in co-infected patients, and we can effectively manage their treatment and follow-up.