In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase

KAYA M. O., Gul G. C., Kurtulus F.

CELLULAR AND MOLECULAR BIOLOGY, cilt.63, sa.12, ss.25-28, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.14715/cmb/2017.63.12.7
  • Dergi Adı: CELLULAR AND MOLECULAR BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.25-28
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Xanthine Oxidase (XO) is related with different diseases such as vascular, gout, nephropathy and renal stone diseases that are relevant to high uric acid levels and oxidative stress. Some common natural inhibitors of xanthine oxidase are known as rosmarinic acid and apigenin. With this study, we aimed to determine inhibitory effects of originally synthesized new generation transition metal vanadates on Xanthine Oxidase (XO) from bovine milk. Because, Xanthine oxidase inhibitors are typically used in the treatment of gout and nephropathy and renal stone diseases linked to hyperuricaemia. We found considerable IC50 constants for inhibition of XO. Among the synthesized compounds, Cu-V-O was found to be the most active (IC50 = 7.119 mM) for inhibition of XO.